Topic hub
Research Literature
Guided readings of the published literature behind current peptide research questions, with explicit attention to what is preclinical, what is clinical, and what remains unproven.
Biology & Longevity
The Biology of Metabolism and Appetite
Hunger is a regulated signalling system, not a matter of willpower. How gut hormones, adipose signals and hypothalamic circuits set the balance.
August 27, 2026 · 7 min read
Biology & Longevity
Understanding Appetite Signaling
Homeostatic hunger and hedonic wanting run on different circuits. Confusing them explains a lot of contradictory findings.
August 25, 2026 · 6 min read
Biology & Longevity
The Biology of Sleep and Recovery
Slow-wave sleep is where the majority of growth hormone release and glymphatic clearance occur. Why architecture matters more than duration.
August 23, 2026 · 6 min read
Biology & Longevity
The Biology of Focus, Memory and Brain Fog
Attention is not one faculty. It is several separable networks, each with its own neurochemistry and its own failure modes.
August 21, 2026 · 6 min read
Biology & Longevity
The Biology of Cellular Aging
DNA damage, senescence, NAD+ decline, mitochondrial dysfunction and chronic inflammation — the interlinked processes behind biological ageing.
August 19, 2026 · 8 min read
Biology & Longevity
Healthspan vs Lifespan
Adding years to life and adding function to years are different goals, measured with different instruments.
August 17, 2026 · 5 min read
Biology & Longevity
What Is NAD+ and Why Does It Decline?
A redox cofactor, a sirtuin substrate and a PARP substrate at once. Why one molecule sits at the centre of so much metabolic research.
August 15, 2026 · 6 min read
Biology & Longevity
What Is Mitochondrial Health?
Not just ATP output. Membrane potential, dynamics, mitophagy and biogenesis together define whether a mitochondrial population is functioning well.
August 13, 2026 · 6 min read
Biology & Longevity
Why Peptides Are Studied in Aging Research
Specificity, native signalling and tractable synthesis — the three properties that keep short sequences central to longevity biology.
August 11, 2026 · 5 min read
Biology & Longevity
Recovery as a Measured Variable
Heart rate variability, resting heart rate, sleep architecture and subjective load — how recovery became something laboratories quantify.
August 9, 2026 · 5 min read
Biology & Longevity
Inflammation Biomarkers Explained
hs-CRP, IL-6, TNF-α and ESR measure related but distinct things. What each one is actually reporting.
August 7, 2026 · 6 min read
Biology & Longevity
The Future of Healthspan Research
Biological clocks, senolytics, geroprotectors and the trial-design problem that stands between the field and real answers.
August 5, 2026 · 6 min read